GLP-1: the body’s own satiety hormone
GLP-1, short for glucagon-like peptide-1, is produced by certain cells of the intestinal lining as soon as food reaches the gut. The hormone signals satiety to the brain, slows the emptying of the stomach and helps the pancreas regulate blood sugar after eating. It works together with other satiety hormones, such as PYY, and as a counterpart to ghrelin, the hunger hormone.
However, the body’s own GLP-1 is broken down again. Its effect is therefore short and occurs mainly around a meal. GLP-1 medicines are modified so that they resist this breakdown and work over several days. This is why diet can support satiety after eating, but cannot produce an effect like a medicine.